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GMC Sierra 2500 HD Engine Gaskets and Seals
Engine gaskets and seals for the GMC Sierra 2500 HD span the 2001–2024 model years, covering everything from cylinder head gaskets to intake manifold and valve cover sets. Pick your GMC Sierra 2500 HD's year above to narrow the list to engine gaskets and seals with confirmed fitment. Every part shown is checked against our vehicle data.
91 - 120 of 179 results
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Cometic C5489-098 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.100
Part: C5489-098
Vehicle Specific
$140.43
Ships from manufacturer
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Cometic C5489-086 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.100
Part: C5489-086
Vehicle Specific
$140.10
Ships from manufacturer
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1 left at this price
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Cometic C5751-027 MLS Cylinder Head Gasket GM Gen III/IV Bore - for LS1/LS2/LS3/LS6 4.060
Part: C5751-027
Vehicle Specific
$97.39
Ships from manufacturer
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Cometic C5319-051 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 051
Part: C5319-051
Vehicle Specific
$97.41
Ships from manufacturer
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Cometic C5751-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060
Part: C5751-045
Vehicle Specific
$97.41
Ships from manufacturer
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Cometic C5751-036 MLS Cylinder Head Gasket GM Bore - LS1/LS2/LS3/LS6 4.060
Part: C5751-036
Vehicle Specific
$97.39
Ships from manufacturer
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Cometic C5319-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 036
Part: C5319-036
Vehicle Specific
$97.39
Ships from manufacturer
3 left at this price
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Cometic PRO3008T-45 GM Duramax Top End Gasket Kit - LB7 6.6L
Part: PRO3008T-45
Vehicle Specific
$459.76
1 left at this price
2 left at this price
MAHLE JV1715 Victor Reinz Rear Main Seal Engine Crankshaft Seal
Part: JV1715
Vehicle Specific
$10.54
In Stock (8)
MAHLE MS12185X Intake and Exhaust Manifold Combination Gasket
Part: MS12185X
Vehicle Specific
$14.49
2 left at this price
In Stock (10+)
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Cometic C5318-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160 045
Part: C5318-045
Vehicle Specific
$98.30
Ships from manufacturer
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Cometic C5318-070 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160 070
Part: C5318-070
Vehicle Specific
$126.82
Ships from manufacturer
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Cometic C5318-066 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160
Part: C5318-066
Vehicle Specific
$126.82
Ships from manufacturer
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Cometic PRO3011T GM Duramax LMM/LLY Top End Gasket Kit 4.130 Bore .047 MLS
Part: PRO3011T
Vehicle Specific
$563.63
Ships from manufacturer
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Cometic C5764-040 MLS Cylinder Head Gasket GM Vortec Gen VII Big Block - 8100 L18 V8
Part: C5764-040
Vehicle Specific
$108.07
Ships from manufacturer
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Cometic C5764-045 MLS Cylinder Head Gasket GM Vortec Gen VII Big Block - 8100 L18 V8
Part: C5764-045
Vehicle Specific
$114.59
Ships from manufacturer
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Cometic C5751-080 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060
Part: C5751-080
Vehicle Specific
$140.10
Ships from manufacturer
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Cometic C5505-044 LS Gen-3/4 Small Block V8 MLX Cylinder Head Gasket 4.040" Bore .044" Thick
Part: C5505-044
Vehicle Specific
$119.73
Ships from manufacturer
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Cometic C5014-032 GM MLS Cylinder Head Gasket Bore - LS1/LS2/LS3/LS6 4.150 032
Part: C5014-032
Vehicle Specific
$117.72
Ships from manufacturer
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Cometic C5477-060 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.000
Part: C5477-060
Vehicle Specific
$129.83
Ships from manufacturer
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Cometic C5477-030 GM MLS Cylinder Head Gasket Bore - LS1/LS2/LS3/LS6 4.000 030
Part: C5477-030
Vehicle Specific
$98.30
Ships from manufacturer
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Cometic C5751-086 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060
Part: C5751-086
Vehicle Specific
$139.28
Ships from manufacturer
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Cometic C5766-040 MLS Cylinder Head Gasket GM Vortec Gen VII Big Block - 8100 L18 V8
Part: C5766-040
Vehicle Specific
$110.19
Ships from manufacturer
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Cometic C5489-140 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.100
Part: C5489-140
Vehicle Specific
$231.78
Ships from manufacturer
What's here for your GMC Sierra 2500 HD
- Engine cylinder head gaskets
- Engine intake manifold gasket sets
- Engine valve cover gasket sets
- Engine valve cover gaskets
- Performance and heavy-duty gasket kits
- OE replacement and rubber seal options
The widest selection here comes from Cometic, MAHLE, Victor, and Fel-Pro, offering a range that spans OE-replacement styles, heavy-duty configurations, and performance-oriented kits in various materials and positions — front, rear, and full-set options alike. Other categories GMC Sierra 2500 HD owners shop for: GMC Sierra 2500 HD Shocks and Struts, GMC Sierra 2500 HD Exterior Lights and GMC Sierra 2500 HD Springs and Suspension Parts, or browse all GMC Sierra 2500 HD parts and accessories.