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GMC Sierra 2500 HD Engine Gaskets and Seals

Engine gaskets and seals for the GMC Sierra 2500 HD span the 2001–2024 model years, covering everything from cylinder head gaskets to intake manifold and valve cover sets. Pick your GMC Sierra 2500 HD's year above to narrow the list to engine gaskets and seals with confirmed fitment. Every part shown is checked against our vehicle data.

61 - 90 of 178 results

Best Seller Free Shipping
Picture of Cometic C5317-075 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

Cometic C5317-075 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

31 reviews
Part: C5317-075
Vehicle Specific
$126.82
Ships from manufacturer
Picture for manufacturer Cometic
Best Seller Free Shipping
Picture of Cometic C5751-075 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060

Cometic C5751-075 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060

41 reviews
Part: C5751-075
Vehicle Specific
$126.82
Ships from manufacturer
Picture for manufacturer Cometic
Best Seller Free Shipping
Picture of Cometic C5318-056 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

Cometic C5318-056 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

42 reviews
Part: C5318-056
Vehicle Specific
$126.82
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5477-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.000

Cometic C5477-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.000

65 reviews
Part: C5477-036
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5318-027 MLS Cylinder Head Gasket GM Bore - LS1/LS2/LS3/LS6 4.160

Cometic C5318-027 MLS Cylinder Head Gasket GM Bore - LS1/LS2/LS3/LS6 4.160

67 reviews
Part: C5318-027
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5317-027 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

Cometic C5317-027 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

42 reviews
Part: C5317-027
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5319-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 045

Cometic C5319-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 045

40 reviews
Part: C5319-045
Vehicle Specific
$97.41
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5318-030 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

Cometic C5318-030 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

71 reviews
Part: C5318-030
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5477-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.000

Cometic C5477-045 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.000

66 reviews
Part: C5477-045
Vehicle Specific
$97.41
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5319-040 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 040

Cometic C5319-040 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190 040

71 reviews
Part: C5319-040
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5319-060 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190

Cometic C5319-060 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190

55 reviews
Part: C5319-060
Vehicle Specific
$101.32
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5319-030 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190

Cometic C5319-030 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.190

40 reviews
Part: C5319-030
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5318-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

Cometic C5318-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.160

59 reviews
Part: C5318-036
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5317-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

Cometic C5317-036 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

77 reviews
Part: C5317-036
Vehicle Specific
$97.39
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of MAHLE HS54660A Engine Cylinder Head Gasket - Set

MAHLE HS54660A Engine Cylinder Head Gasket - Set

20 reviews
Part: HS54660A
Vehicle Specific
$316.50
2 left at this price
Picture for manufacturer MAHLE
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Picture of Cometic C5751-140 MLS Cylinder Head Gasket GM Bore - LS1/LS2/LS3/LS6 4.060

Cometic C5751-140 MLS Cylinder Head Gasket GM Bore - LS1/LS2/LS3/LS6 4.060

40 reviews
Part: C5751-140
Vehicle Specific
$228.77
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of MAHLE HS54232 Victor Reinz Engine Cylinder Head Gasket Set

MAHLE HS54232 Victor Reinz Engine Cylinder Head Gasket Set

52 reviews
Part: HS54232
Vehicle Specific
$275.52
2 left at this price
Picture for manufacturer MAHLE
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Picture of Edelbrock Cylinder Head Gasket Set

Edelbrock Cylinder Head Gasket Set

75 reviews
Vehicle Specific
from $50
In Stock (10+)
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Picture of Mr. Gasket Valley Pan Cover Bolt Sets for GM LS Engines

Mr. Gasket Valley Pan Cover Bolt Sets for GM LS Engines

57 reviews
Vehicle Specific
from $44
In Stock (10+)
Picture for manufacturer Mr. Gasket
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Picture of Mr. Gasket Lifter Valley Gaskets

Mr. Gasket Lifter Valley Gaskets

55 reviews
Vehicle Specific
from $50
In Stock (10+)
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Picture of MAHLE Victor Reinz Valve Cover Grommet Set

MAHLE Victor Reinz Valve Cover Grommet Set

33 reviews
Vehicle Specific
from $6
In Stock (10+)
Picture for manufacturer MAHLE
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Picture of MAHLE Engine Oil Pump Pickup Tube Gasket

MAHLE Engine Oil Pump Pickup Tube Gasket

55 reviews
Vehicle Specific
from $4
In Stock (10+)
Picture for manufacturer MAHLE
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Picture of Cometic C5751-098 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060

Cometic C5751-098 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.060

57 reviews
Part: C5751-098
Vehicle Specific
$140.43
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5764-060 MLS Cylinder Head Gasket GM Vortec 8100 Gen-VII 4.280" Bore Left Side

Cometic C5764-060 MLS Cylinder Head Gasket GM Vortec 8100 Gen-VII 4.280" Bore Left Side

45 reviews
Part: C5764-060
Vehicle Specific
$144.81
Ships from manufacturer
Picture for manufacturer Cometic
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Picture of Cometic C5489-120 GM MLS Cylinder Head Gasket Bore - LS1/LS2/LS3/LS6 4.100

Cometic C5489-120 GM MLS Cylinder Head Gasket Bore - LS1/LS2/LS3/LS6 4.100

52 reviews
Part: C5489-120
Vehicle Specific
$232.11
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5489-086 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.100

Cometic C5489-086 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.100

67 reviews
Part: C5489-086
Vehicle Specific
$140.10
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5764-066 MLS Cylinder Head Gasket GM Vortec Gen-VII Big Block - 8100 L18 V8

Cometic C5764-066 MLS Cylinder Head Gasket GM Vortec Gen-VII Big Block - 8100 L18 V8

16 reviews
Part: C5764-066
Vehicle Specific
$147.82
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5761-066 MLS Cylinder Head Gasket GM Vortec Gen VII Big Block - 8100 L18 V8

Cometic C5761-066 MLS Cylinder Head Gasket GM Vortec Gen VII Big Block - 8100 L18 V8

26 reviews
Part: C5761-066
Vehicle Specific
$144.81
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5317-089 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

Cometic C5317-089 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130

8 reviews
Part: C5317-089
Vehicle Specific
$140.10
Ships from manufacturer
Picture for manufacturer Cometic
Free Shipping
Picture of Cometic C5317-080 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130 080

Cometic C5317-080 MLS Cylinder Head Gasket GM Gen III/IV Bore - LS1/LS2/LS3/LS6 4.130 080

43 reviews
Part: C5317-080
Vehicle Specific
$140.10
Ships from manufacturer
Picture for manufacturer Cometic

What's here for your GMC Sierra 2500 HD

  • Engine cylinder head gaskets
  • Engine intake manifold gasket sets
  • Engine valve cover gasket sets
  • Engine valve cover gaskets
  • Performance and heavy-duty gasket kits
  • OE replacement and rubber seal options

The widest selection here comes from Cometic, MAHLE, Victor, and Fel-Pro, offering a range that spans OE-replacement styles, heavy-duty configurations, and performance-oriented kits in various materials and positions — front, rear, and full-set options alike. Other categories GMC Sierra 2500 HD owners shop for: GMC Sierra 2500 HD Shocks and Struts, GMC Sierra 2500 HD Exterior Lights and GMC Sierra 2500 HD Springs and Suspension Parts, or browse all GMC Sierra 2500 HD parts and accessories.