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GMC Sierra 2500 Engine Parts

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100 100 Series 100-22 100-24 1000 1000 Series 102-22 150 150-22 150-24 1500 1500 Series 250 250-22 250-24 2500 2500 Series 253-22 280-22 300 300-24 3000 350-24 350-27 350-8 3500 370 AC100 AC150 AC250 AC252 AC300 Acadia Acadia Limited AF240 AFP240 Astro B3500 B6000 B7 Brigadier C10 C10 Panel C10 Suburban C15 C15 Suburban C15/C1500 C15/C1500 Pickup C15/C1500 Suburban C1500 C1500 Pickup C1500 Suburban C20 C20 Suburban C25 C25 Suburban C25/2500 C25/C2500 C25/C2500 Pickup C25/C2500 Suburban C2500 C2500 Pickup C2500 Suburban C30 C30 Panel C35 C35/C3500 C35/C3500 Pickup C3500 C3500 Pickup C3500HD C4500 Topkick C5000 C5000 Topkick C5500 Topkick C6000 C6000 Topkick C6500 Topkick C7000 C7000 Topkick C7500 Topkick Caballero Canyon CC100 CC101 CC102 CC150 CC250 CC260 CC300 CCV100 CCX250 CK Denali EC 250 EC100 EC101 EC102 EC150 EC152 EC250 EC251 EC252 EC280 EC282 EC283 EC350 EF240 EF241 EF242 EF350 EFP240 Envoy Envoy XL Envoy XUV F-350 F350 F350-24 F350-27 F370 FC100 FC100-22 FC101 FC102 FC150 FC152 FC250 FC251 FC252 FC253 FC280 FC281 FC283 FC300 FC350 FCS300 FCS350 FF350 FM340 FM350 Ford 300 FP152 G1000 Series G15 G15/G1500 Van G1500 G25 G25/G2500 Van G2500 G35 G35/G3500 Van G3500 Giulia Sprint Hummer EV Hummer EV Pickup Hummer EV SUV I1000 I1500 I2500 I3500 Jimmy K10 K10 Suburban K1000 K1000 Pickup K15 K15 Suburban K15/K1500 K15/K1500 Pickup K15/K1500 Suburban K1500 K1500 Pickup K1500 Suburban K20 K20 Suburban K25 K25 Suburban K25/K2500 K25/K2500 Pickup K25/K2500 Suburban K2500 K2500 Pickup K2500 Suburban K35 K35/K3500 K35/K3500 Pickup K3500 K3500 Pickup L3500 LI3500 M300 M340 M350-24 M350-27 P1000 P15 P15/P1500 Van P150-22 P1500 P152 P25 P25/P2500 Van P2500 P252 P253 P30 P35 P35/P3500 Van P3500 P4500 P6000 P6500 PB1000 Series PB15 Series PB1500 Series PB25 Series PB2500 Series PB2500 Van PB3500 Van Pickup PM150 PM150-22 PM150-24 PM151 PM152 PM152-22 PM153 PM250 PM250-24 PM251 PM252 PM253 PV1000 R1500 R1500 Suburban R2500 R2500 Suburban R3500 S15 S15 Jimmy S300 S300-24 S370 Safari Savana 1500 Savana 2500 Savana 3500 Savana 4500 Sierra Sierra 1500 Sierra 1500 Classic Sierra 1500 HD Sierra 1500 HD Classic Sierra 1500 Limited Sierra 2500 Sierra 2500 HD Sierra 2500 HD Classic Sierra 3500 Sierra 3500 Classic Sierra 3500 HD Sierra C3 Sierra EV Sierra Nueva Sonoma Sprint Suburban Syclone T14 T145 T14A T14B T15 T155 T16L T6500 T7500 Terrain Topkick Tracker Transmode Truck Typhoon V1500 V1500 Suburban V2500 V2500 Suburban V3000 Forward Control V3500 Van W3500 Forward W4500 Forward W5500 Forward W5500HD Forward Yukon Yukon XL Yukon XL 1500 Yukon XL 2500
2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999

This page brings together engine parts for the GMC Sierra 2500, covering model years 1999 through 2014. The range spans cylinder block components, valve train parts, gaskets and sealing systems, and bearings — available in both OE-replacement and performance configurations. Choose your model year above and this page keeps only the engine parts that fit your GMC Sierra 2500. Each listing is matched to our vehicle fitment data before it appears here.

Shop GMC Sierra 2500 Parts by Category

Cylinder Block Components
Cylinder Block Components
Valve Train Components
Valve Train Components
Gaskets and Sealing Systems
Gaskets and Sealing Systems
Service Kits
Service Kits
Filters
Filters
Bearings
Bearings
Control Modules
Control Modules
Wire, Cable and Related Components
Wire, Cable and Related Components
Sensors
Sensors
Switches
Switches
Electrical Connectors
Electrical Connectors
Sending Units
Sending Units

What's here for your GMC Sierra 2500

  • Cylinder block components, including front and rear positions
  • Valve train components, available in single and dual configurations
  • Gaskets and sealing systems, including manifold gaskets and full kits
  • Bearings for internal engine assembly

The widest selection here comes from MAHLE, COMP Cams, ACDelco, and Victor, covering both OE-replacement and performance-oriented parts across the range. Other categories GMC Sierra 2500 owners shop for: GMC Sierra 2500 Exterior Lights, GMC Sierra 2500 Doors and Door Parts and GMC Sierra 2500 Body and Paint Equipment, or browse all GMC Sierra 2500 parts and accessories.